Effects of General Anesthesia on Brain FC and Cognition in Children With Potential Neurological Damage

Postoperative Cognitive Dysfunction(POCD)is a common postoperative complications, existing clinical research focused on the adult patients, ignoring that the developing human brain with underlying neurological impairments may be at higher risk for cognitive impairment, so we need a prospective study, observe this kind of "special groups" in the brain structure and function of before and after general anesthesia, To determine the susceptibility to neurotoxicity of general anesthesia drugs.

Inclusion Criteria:Age 4 to 10 years old, both sexes;Apgar score ≥8 at birth;ASA (American Society of Anesthesiologists Physical Condition Rating) ⅰ-ⅲ;to be treated with SDB under general anesthesia;His legal guardian has signed the informed consent -Exclusion Criteria:Age < 4 years old; or age >10 years old;suffering from serious heart, lung and brain diseases;History of dystocia or perinatal cerebral ischemia and hypoxia;Gestational age at birth ≤32 weeks;Confirmed or suspected neurological retardation or hearing and vision abnormalities;suffering from malignant tumor;had received general anesthesia or deep sedation before enrollment