Biomarkers of Metabolic Obesity.

The main aims of the work: Analysis of the concentration of selected pro-inflammatory parameters in blood serum and saliva of people with different distribution of subcutaneous and visceral adipose tissue. Analysis of metabolic obesity biomarkers in saliva and blood serum. Evaluation of new diagnostic methods for the early determination of the risk of metabolic obesity and its complications.Based on the inclusion and exclusion criteria the observational study was conducted among 119 people (79 women and 41 men). Study group included 79 people (48 women and 31 men with obesity), and control group included 41 people (31 women and 10 men with normal body weight).The study consisted of three visits. The first included qualification for the study, body composition measurements, ankle-brachial index test and completing the questionnaires and 3-day nutrition diaries. At the second visit blood was collected to conduct the morphological test. At the third visit saliva was collected to determine the proinflammatory cytokine and adipokine concentration.

Inclusion Criteria:women and men aged 20-55primary obesitycertificate from the dentist confirming the absence of periodontitis and inflammation in the oral cavity.Exclusion Criteria:secondary obesity,type I and II diabetes,exacerbated coronary artery disease,endocrine disorders,eating disorders,pregnancy and lactation period,use of hormonal contraception or hormone replacement therapy, steroid therapy, antiretroviral therapy,surgical or pharmacological history obesity treatment,pacemaker