Associations Between the Oral and Intestinal Icrobiome and Neovascular Age-related Macular Degeneration

Sex: All

Ages: 40 Years – N/A

Healthy volunteers: 1

Phase: PHASE3

Enrollment: 45

Sponsor: Seoul National University Bundang Hospital

Summary

A pilot study for Associations between the oral and intestinal microbiome and neovascular age-related macular degeneration and the investigation on the effect of oral probiotics as a treatmentThe investigators recruit the neovascular AMD patients and control patients.15 neovascular AMD patients with anti-VEGF treatment and oral probiotics supplement15 neovascular AMD patients with anti-VEGF treatment and no oral probiotics supplement15 control patients and no oral probiotics supplementThe investigators will collect stool, blood, and saliva sample at the baseline and 6 months, and analyze the oral and intestinal microbiome changes.

Eligibility Criteria

Inclusion Criteria:Normal BMI patientsDiagnosed as neovascular AMD (experimental & sham group)Normal patients (control group)Exclusion Criteria:Obese (BMI > 25)Past surgical history involving intestinal diseasesPrevious oral antibiotic treatment before 1 week at the baseline enrollPrevious oral probiotics supplementPrevious ophthalmic retinal diseases except neovascular AMD

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05604989). StuddyBuddy aggregates publicly available trial information.