PCP in Immunocompromised Population in Southern China

To evaluate the sensitivity and specificity of the combined detection system for the diagnosis of pneumocystis infection in immunocompromised population in Southern China.

Inclusion Criteria:Patients with immunocompromised conditions, including but not limited to HIV infection, long-term systemic use of corticosteroids, use of immunosuppressive agents, hematologic malignancies, solid tumors, hematopoietic stem cell transplantation, solid organ transplantation, radiotherapy and/or chemotherapy for malignancies,primary immunodeficiency disease.Patients with typical clinical manifestations of PJP such as fever,nonproductive cough, shortness of breath, and progressive hypoxemia.Patients with radiological abnormalities suggestive to PJP in bilateral lungs revealed by chest computed tomography (CT).Respiratory tract samples were collected for qPCR and/or mNGS detection.Exclusion Criteria:Patients who were unable to obtain a respiratory specimen.Medical record was incomplete.