The Role of Intestinal Ultrasound in Monitoring the Response to Biological Therapy in Patients With Ulcerative Colitis

In this study, the investigators aim to evaluate the role of intestinal ultrasound in evaluation of the therapeutic response to biological therapy in patient with ulcerative colitis

Inclusion Criteria:Any patient above age of 18 years old and diagnosed to have UC and whom not responding to conventional medical therapy and eligible for biological therapy will be recruited in this studymoderate to severe UC patientsimmunosuppressant or corticosteroid refractory diseasethose with intolerance or contraindication to conventional therapies are eligible to be treated with biological therapyExclusion Criteria:Patients with UC who are under age of 18 years' oldPatients with UC who aren't eligible to biological therapypatients with complication of UC(fistula , intestinal obstruction , intestinal perforation ,……)Patient refuse to participate in the study.