Duloxetine Impact on Postoperative Pain Control and Outcomes

Conditions: Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use, Opioid Addiction

Sex: All

Ages: 24 Years – 99 Years

Healthy volunteers: 1

Phase: PHASE2

Enrollment: 130

Sponsor: Scripps Health

Summary

Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption.Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative pain, function, and quality of life.Evaluate the correlation between preoperative screening tests (measuring pain centralization, anxiety, depression, and overall function) and patients' response to treatment (reduction in pain, anxiety, or depression and improvement in function).

Eligibility Criteria

Inclusion Criteria:Age: > 24 yearsMale / Female not meeting any of the exclusion criteriaExclusion Criteria:Age < 24 yearsCurrent use of antidepressant medications (including SSRI/SNRI, tricyclic, or Monoamine Oxidase Inhibitors)History of seizure disorderDiagnosis of bipolar disorderHistory of syncope/orthostatic hypotensionDiagnosis of any condition with slowed gastric emptyingHistory of suicidal ideationHistory of liver diseaseHistory of chronic kidney disease/renal impairmentHistory of angle-closure glaucoma.

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05611749). StuddyBuddy aggregates publicly available trial information.