Biodistribution and Pathophysiology Study of 11C-para-aminobenzoic Acid

The investigators will perform radionuclide PET scans in subjects with infectious diseases to assess whether radio-labeled PABA (11C-PABA) is effective for infection imaging.Tomographic imaging can be used to evaluate disease processes deep within the body, noninvasively and relatively rapidly. The goal is to see if this imaging technique can help differentiate infections from non-infectious processes and also provide information on the causative bacterial class.

Inclusion Criteria:Male or female ≥18 years of age at the time of consent and imagingThose with confirmed diagnosis of infection at any body site OR clinical and imaging evidence of suspected infection in any body site OR confirmed inflammatory oncologic disease.Assessed to be in stable condition to participate in the studySubject is judged by the investigator to have the initiative and means to be compliant with the protocol.Subjects or their legal representatives must have the ability to read, understand and provide written informed consentExclusion Criteria:PregnancyLactating femalesHistory of significant renal or hepatobiliary diseasesInadequate venous accessAdministered a radioisotope within 5 physical half-lives prior to study enrollmentTreated with an investigational drug / biologic / therapeutic device within 30 days prior to studyDetermined to have prior (external) radiation exposure of 5 rems in past year