A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Inclusion Criteria:Patients aged 18-70 years of both sexesASA I-III PatientsExclusion Criteria:Obesity,Chronic Kidney Disease,Chronic Renal Failure,Acute Renal Failure,Peripheral and ischemic vascular disease,Chronic Heart Failure,History of anaphylaxis,A-V block,Creatinine level >1.4,Neuromuscular disease,Malignant hypertension,Pyelonephritis,Urinary tract infectio,Severe inflammation/possible sepsis,Active malignancy,Patients with surgery reversion to laparotomy,Hemodynamic instability, need for vasopressors,Severe bleeding requiring blood transfusion,