Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study

The goal of this observational study is to describe the immune signature of acute pulmonary infection.The main questions it aims to answer are:Nasal mucosal immune response in patients with influenza infectionDifference of immune response between Viral sepsis and Bacterial sepsisImmunological differences between Viral sepsis and Viral pneumonia

Inclusion Criteria:Age ≥18 years at time of signing Informed Consent Formchest imaging confirmed pneumonia.Informed consent is obtainedThe pneumonia onset ≤8 daysExclusion Criteria:SaO2/SPO2≤94% on room air or Pa02/Fi02 ratio <300mgHg before the onset of pneumoniaSevere liver disease (e.g. Child Pugh score ≥ C, AST>5 times upper limit)Patients with known severe renal impairment (estimated glomerular filtration rate ≤30 mL/min/1.73 m2) or receiving continuous renal replacement therapy, hemodialysis,peritoneal dialysis）Pregnant Or Lactating WomenPatients were eligible for organ transplantation or had undergone previous organ transplantation surgeryHIV infectionHad unstable angina or myocardial infarction within 30 days without vascular recanalization treatment