Confounding Factors of Chronic Endometritis in Women With Reproductive Failure

The aim of the study is to investigate the confounding factors of chronic endometritis and therapeutic benefits of antibodies targeting plasma cells in women with reproductive failure.

Inclusion criteria:Age 20-45 years;Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation12; orWomen who failed to conceive after unprotected intercourse for one year; orWomen who failed failure to achieve a clinical pregnancy after two consecutive cycles of IVF, ICSI or frozen embryo replacement cycles where the cumulative number of transferred embryos is no less than four for day-2 embryos and no less than 2 for day-5 embryos (blastocysts), with all embryos being of good quality.Exclusion criteriaUncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural);Untreated hydrosalpinx;History of antiphospholipid syndrome;Known clinical autoimmune disease;Undergoing immunotherapy;Abnormal thyroid function;Abnormal karyotyping.Those with active pelvic inflammatory disease or suspicion of infection etc.