Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings

The primary objective of this trial is to determine whether insulin glargine reduces the risk of serious hypoglycemia or improves Time in Range at 6 months when compared against standard of care human insulin (e.g. NPH or premixed 70/30) among youth living with type 1 diabetes (T1D) in low resource settings.

Inclusion Criteria:Children and young adults (age 7-25)Have a clinical diagnosis of type 1 diabetes (T1D)Exclusion Criteria:Prior use of any insulin analoguePatients (or parents for children <18 years old) who refuse to or cannot provide informed consentWho are currently pregnant or plan to become pregnant over the next yearWho have previously used a continuous glucose monitor (CGM) for glucose monitoringWho were first diagnosed with T1D less than 12 months agoWho is diagnosed with severe malnutrition