A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])

To investigate the dose response in respect of weight decrease following repeated oral administration of OPC-131461 at 1, 2, 5, and 10 mg or placebo in patients with CHF with volume overload despite having received diuretics other than vasopressin antagonists

Inclusion Criteria:Subjects with CHF with lower limb edema, pulmonary congestion, or jugular venous distension due to volume overload.Subjects undergoing any of the following diuretic therapiesLoop diuretics at a dosage equivalent to 40 mg/day or more of furosemide tablet/fine granuleConcomitant administration of a loop diuretic and a thiazide diuretic (including similar drugs) at any dosesConcomitant administration of a loop diuretic and a mineralocorticoid receptor antagonist or potassium-sparing diuretic at any dosesSubjects who were currently hospitalized or who are able to be hospitalizedExclusion Criteria:Subjects with acute heart failureSubjects with an assisted circulation deviceSubjects who cannot sense thirst or who have difficulty in ingesting water