Comparison of Body Weight Change Through Different Smeglutide Administration Methods

Investigators determined to detect the effect of smeglutide on body weight and metabolic indexes among overweight and obese participants through two different dosing programs.

Inclusion Criteria:18 ≤ age<75;Overweight or obesity: meet either one of the following standardsPatients with BMI ≥ 24 kg/m2 and at least one obesity complication (hypertension, hyperlipidemia, apnea syndrome, cardiovascular disease)Simple obese patients with BMI ≥ 28kg/m2Abdominal obesity, waist circumference ≥ 90 cm for males and ≥ 80 cm for femalesExclusion Criteria:Have a personal or family history of medullary thyroid carcinoma (MTC) or have multiple endocrine neoplasia type 2 (MEN-2) patients.Patients with severe hypersensitivity to smeglutide or any other excipient component.Diabetic patients (glycosylated hemoglobin ≥ 6.5% or fasting blood glucose ≥ 7.0 mmol/L or blood glucose ≥ 11.1 mmol/L 2 hours after meal or random blood glucose ≥ 11.1 mmol/L).Triglyceride>5.6mmol/L;Participants in other clinical drug trials in recent three months.The range of weight change in recent 90 days is>5kg.Cushing's syndrome and abnormal thyroid function.Pregnant or breastfed women.The study doctor judged that it was not suitable to participate in the test.