Laser Versus Cryotherapy for the Treatment of Recalcitrant Warts

To evaluate whether laser was superior to cryotherapy for recalcitrant warts

Inclusion Criteria:Patients with HPV2/27/57-induced recalcitrant warts, including periungualor mosaic warts, common or plantar warts with a duration of longer than 1 year, and common or plantar warts previously received no more than two sessions of cryotherapyTotal number of warts is ≤10 .Aged 18 years or older.Exclusion Criteria:Patients are currently participating in another trial for the treatment of cutaneous warts.Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months.Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism.Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases).Patients are pregnant or ready for pregnancies or breast-feeding.Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome).Patients have local pain intolerance.Patients have local hypoesthesia.Patients are unable to tolerate laser or cryotherapy.