Vinegar-induced Collection of Duodenal Pancreatic Juice Via Endoscopic Ultrasound

The goal of this clinical trial is to learn about the feasibility of collecting pancreatic juice through duodenal aspiration by ultrasound endoscopy (EUS) for molecular marker testing after intraduodenal infusion of vinegar in patients with suspected pancreatic cancer and who are scheduled to have endoscopic ultrasound with fine needle aspiration (EUS-FNA). The main questions it aims to answer are:Is vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound feasible?What is the best operating condition (amount of vinegar, collection time, etc.) of vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound?Participants will have EUS as scheduled, during which different amount of vinegar will be infused into duodenum and then pancreatic juice be collected for different time via suction by EUS.Researchers will compare the amount of collected pancreatic juice and molecular marker level in different groups to determine the best operating condition for vinegar-induced collection of duodenal pancreatic juice via endoscopic ultrasound.

Inclusion Criteria:Age: 18 years old or olderDiagnosis: CT, MRI, transabdominal ultrasound or other imaging examinations showed a pancreatic mass, and 3 endoscopists agreed on the diagnosis of suspected pancreatic cancerEUS-FNA is required to perform further treatment strategyThe patient can understand the study protocol, is willing to participate in the study and can provide written informed consentExclusion Criteria:The patient's clinical and imaging features do not support the diagnosis of suspected pancreatic cancer, judged by 3 endoscopistsThe patient refuses to have EUS-FNAThe patient is unsuitable for EUS-FNA because of his/her general condition, or contraindicated for anesthesiaThe patient's imaging suggests severe pancreatic duct obstructionThe patient cannot understand the conditions and objectives of this study, or refuse to participate in the study