Salicylic Acid Versus Cryotherapy for the Treatment of HPV1-induced Plantar Warts

To evaluate whether salicylic acid was superior to cryotherapy for plantar warts

Inclusion Criteria:Patients with HPV1-induced plantar warts.Total number of warts is ≤5.Aged 12 years or older.Exclusion Criteria:Patients are currently participating in another trial for the treatment of plantar warts.Patients had received two or more consecutive sessions of cryotherapy, with an interval of no more than 4 weeks (The history of salicylic acid treatment was not considered as criteria for exclusion because high concentration salicylic acid is not commercially available in Chinese mainland).Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months.Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism.Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases).Patients are pregnant or ready for pregnancies or breast-feeding.Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome).Patients have local pain intolerance.Patients have local hypoesthesia.Patients are unable to tolerate salicylic acid or cryotherapy.