Pediatric POTS: Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.

Inclusion Criteria:Females 12-18 years oldAble to communicate and provide consent/assentEnglish speakingDiagnosed with POTS (POTS will be defined standardly as a symptomatic = 40 bpm rise in heart rate on tilt table study without a drop in blood pressure and with symptoms of orthostatic intolerance clinically)Right-handedAge-matched healthy control subjects: no POTS or other neurological disordersExclusion Criteria:Left-handedInflammatory arthritis, connective tissue or auto-immune disorderAny chronic neurological disorder besides POTSEvidence of unstable medical disorder, such as kidney (rising creatinine, or end-stage renal failure) or liver impairment (rising AST or ALT, or end-stage with coagulopathy), poorly controlled significant cardiovascular (CHF), respiratory, endocrine (diabetes