Topical Ethanol Extract (Piper Crocatum) for Anogenital Warts

This clinical trial aims to assess the efficacy of topical Piper crocatum in treating Anogenital warts. It aims to answerthe clinical efficacy of treating anogenital wartsthe expression of Foxp3+ regulatory T (Treg), TGF/Tumor Growth Factor -β1, and IFN/interferon -γ of anogenital wart lesion Participants will be allocated into two topical treatments, intervention and active comparator Trichloroacetic Acid (TCA) 90%. The researchers assume that intervention is superior compared to TCA 90%

Inclusion Criteria:Men and women diagnosed with external anogenital wartsClinical lesions of Anogenital Wart at least 3 lesions with a size of 1-5 cmIn patients with HIV, Cluster of Differentiation 4 (CD4)cell count >350 cells/mm and have been taking antiretroviral (ARV) drugs regularly for 3 months,Exclusion Criteria:Pregnant or lactating womenLesions located in the external urethral orifice and vaginaUsing systemic immunomodulators/immunosuppressantsThe protocol treatment will be discontinued if patientsa. Withdraw their consent based on the patient's demand d. Severe adverse events occurred or allergies to the components of the test product b. After undergoing clinical trials, the patient experienced things that caused him/her to no longer meet the criteria set out in this protocol. c. Subjects do not comply the established study protocol