Effects of Dietary Fiber on Bone Metabolism

Clinical and animal studies have found that sepsis can lead to a serious imbalance in the gut microecology, a reduction in probiotics, a reduction in short-chain fatty acid, a reduction in bone mass, and an increase in bone destruction, maintaining the stability of microecology can be one of the effective means of bone protection. But at present, the treatment of sepsis with early supplementation of probiotics is still controversial, and dietary fiber intake has significantly changed the composition of the microbiota, it may be a safe and effective method to prevent bone loss in sepsis. Further study on it will provide reliable theoretical basis and intervention target for early, safe and effective prevention of osteoporosis.

Inclusion Criteria:The subjects voluntarily cooperated with the study and signed the informed consent form, and could be followed upAge 18-70It meets the diagnostic criteria of Sepsis 2016 Sepsis 3.0 guidelinesAfter treatment, the Hemodynamics is stable and the patient is ready to start enteral nutrition supportThose who need tube feeding for more than 14 days because of the need of illness and can not take food by mouthExclusion Criteria:People who have had osteoporosis in the pastAdmission due to fractureThe shock was not corrected, and the patients were maintained with a large amount of vaso-active drugs (0.5 ug/kg/min of noradrenaline) , but could not be given enteral nutritionSupplement with probiotics or prebiotics aloneParturientsNo written informed consent