Neural Mechanism of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait

To investigate the treatment effect of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients with freezing of gait (FOG) and the underlying neural mechanism.

Inclusion Criteria:diagnosis of FOG with expertise in movement disorders.the score of item 3 of the FOG questionnaire ≥1.ongoing treatment with a stable dose of any medication for 2 months.40 years of age or older.Exclusion Criteria:a history of addiction, psychiatric disorders, or neurological diseases other than PD.focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images.anti-PD medication adjustments during rTMS treatment.history of substance abuse within the past 6 months.nonremovable metal objects in or around the head.previously received rTMS treatment.prior history of seizure or history in first-degree relatives.