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NCT05629520
A Neurobiological Model of Anhedonia
Conditions: Anhedonia, Depression
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: 1
Enrollment: 60
Sponsor: Milton S. Hershey Medical Center
Location: United States
Summary
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
Eligibility Criteria
Inclusion Criteria:Current diagnosis of MDD based on the MINI International Neuropsychiatric Interview (MINI)For treatment resistant depression participants: unsuccessful treatment with at least 2 types or doses of antidepressant medication treatmentRight-handedCapacity for informed consentScore a 9 or higher on the MADRSExclusion Criteria:Comorbid Bipolar DisorderSubstance use disorder in the last 12 monthsSchizophrenia, and other psychotic disordersComorbid illness such as endocrinological illness (e.g.
Cushing's disease) rheumatologic illness (e.g., systemic Lupus erythematosus, current treatment with glucocorticoids), and autoimmune diseases (e.g.
psoriasis)PregnancyDaily NSAID or aspirin use and any metallic implantVisual/Hearing Impairments that would keep participant from being able to complete tasks
Source: ClinicalTrials.gov (NCT05629520). StuddyBuddy aggregates publicly available trial information.
