Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen

Pain is an inseparable symptom of fractures and is the most important and common symptom that brings patients to medical centers; Therefore, paying attention to pain and its control is very important in the examination and treatment of fractures, and painkillers are usually needed for effective pain control. About 70-90% of the patients who go to the emergency room due to injuries have organ injuries. Among these patients, those who suffer from fractures endure severe pain, and since only 10% of patients have open fractures, the pain management of patients with closed fractures is particularly important. Various medicinal compounds have been used so far to control the pain of fractured patients, including opioid compounds such as morphine, non-steroidal anti-inflammatory drugs such as ibuprofen and acetaminophen. Opioids are the main drug class for pain control in fractures, but since they have significant side effects, various studies have been conducted in the field of comparing the anti-inflammatory effect of different drugs in fractures, and the effect of various combinations compared to opioids has been investigated. Non-steroidal anti-inflammatories are always considered as an alternative to opioids and acetaminophen has also been considered to reduce the dosage of opioids, so in this study the effect of three combinations of intravenous morphine and ibuprofen plus intravenous acetaminophen and intravenous ibuprofen on pain levels in patients with a closed limb fracture will be investigated.This study is a blind randomized clinical trial, which investigates and compares the effect of intravenous morphine (Daropakhsh Company) with intravenous ibuprofen (Caspian Taamin Company) and intravenous acetaminophen (Caspian Taamin Company) with intravenous ibuprofen (Caspian Taamin Company) in reducing the pain of patients with closed limb fractures. The population investigated in this study will include all patients referred to the emergency room of Al-Zahra and Ayatollah Kashani educational centers in Isfahan city in 2022-2023.

Inclusion Criteria:Diagnosing a closed fracture of any of the bones of the body by an emergency medicine specialistInformed consent of the patient or his family to participate in the studyAge 18 to 55 yearsPain score of higher than or equal to 6 on the VAS scaleInformed consent of the patient or family during the studyNo history of liver or kidney failureNo history of gastrointestinal bleedingNo history of heart failureNo history of allergy to study drugsAbsence of addiction (the patient is asked)Not decreased level of consciousnessLack of evidence of increased intra-cerebral pressureNot having an open fractureAbsence of breathing disorders and respiratory problemsNo history of asthmaLack of history of frequent use of painkillersNot receiving any form of pain killer in the last few hoursExclusion Criteria:Occurrence of any type of drug reaction or unusual complication during the study periodSimultaneous Head traumaSimultaneous damage of nerves and blood vesselsMultiple fracturesFracture other than limbEvidence of increased intra-cerebral pressureDecreased level of consciousnessBreathing disorders and respiratory problems