Project CADENCE (CAncer Detected Early caN be CurEd)

With existing evidence showing the difference in miRNA expression levels between non-cancer and cancer groups, the investigators assume that levels of DNA methylation, RNA expression as well as protein concentration will also be dysregulated during disease progression. Combining the power of multi-omic cancer biomarkers, the investigators hypothesize that the sensitivity and specificity of MiRXES MCST can be significantly improved compared to existing multi-cancer diagnostic tests.In this study, the investigators propose to develop and validate blood-based, multi-cancer screening tests through a multi-omics approach.

Inclusion Criteria:Healthy average-risk cohort Individuals representing the general population who self-declare to have no cancer history and have no indications suggestive of underlying cancer development. Subjects will be recruited from a state-of-the-art population study.Increased-risk (genetic/familial) cohort Individuals carrying certain germline mutations that predispose the subjects to an increased risk of having cancer than the general population. Subjects will be recruited from Cancer Genetics Service (CGS).High-risk cohort Individuals diagnosed with diseases that have a high risk of progressing to cancer. A total of 600 subjects (200 subjects for each Phase 1B, 1C, and 1D) will be recruited by the lead PI of each cancer type.Malignant cohort Individuals diagnosed with cancer. A total of 600 subjects (200 subjects for each Phase 1B, 1C, and 1D) will be recruited by the lead PI of each cancer type. Wherever possible, samples for the 'Malignant group' should have a representation of each cancer stage.Exclusion Criteria:Pregnant or lactating (self-declaration), unwilling or unable to provide signed informed consent and has or had received chemotherapy or radiotherapy for cancer treatment and/or any other cancer-related treatment.