Uric Acid Based Renal Stones: Clinical, Metabolic and Genetic Characterization

Reporting prevalence of uric acid based renal stones among patients with nephrolithiasis admitted to Mansoura Urology and Nephrology center (MUNC).Furthermore, identification of monogenic and polygenic uric acid stone formers.Identification of factors associated uric acid stone recurrence as well as determinants of laterality in patients with uric acid based renal stones

Inclusion Criteria:⦁ Patients with unilateral renal stones (denovo or recurrent) who are candidates for endoscopic treatment (percutaneous nephrolithotomy).Patients with preoperative NCCT findings of renal stone with stone density equal or less than 600HU.Patients with dominant uric acid composition will be included as proven by postoperative stone analysisExclusion Criteria:⦁ Patients with anatomical abnormalities precipitating stone disease e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, Urinary diversion, History of ureterovesical re-implantationPatients with non-uric acid stones as proven by post-operative stone analysis.