Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Inclusion Criteria:1) histologically confirmed PAs, 2) Non-function pituitary adenomasExclusion Criteria:1) Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.