Zanubrutinib Plus Rituximab for Patients With Indolent Mantle Cell Lymphoma

Phase II, multicentre, randomised, open-label study to assess the benefit of early intervention with fixed duration, time-limited zanubrutinib-rituximab in indolent mantle cell lymphoma (MCL)

Inclusion Criteria:Male or females 18 years of age or over.Life expectancy ≥ 6 months.Pathologically confirmed MCL, with documentation of monoclonal B cells that have a chromosome translocation t(11;14)(q13;q32) and/or overexpress cyclin D1, D2 or D3.Stage II-IV MCL measurable by CT imaging or by white cell count (WCC)/BM infiltration.'Indolent' MCL, defined as 1 or more of the following:Observation with no treatment for a minimum of 6 months after the initial diagnosisLeukaemic non-nodal variant (lymphocytosis/splenomegaly only without nodal involvement)Low tumour volume (largest lymph node ≤ 3cm in maximal diameter), proliferation fraction (Ki67 or equivalent) ≤30% and classical morphology (non-blastoid/pleomorphic)Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2.Absolute neutrophil count ≥1.0 x 109/L and platelets ≥75 x 109/L independent of growth factor support.AST and/or ALT ≤3 x upper limit of normal (ULN).Total Bilirubin ≤1.5 x ULN unless due to Gilberts syndrome or of non-hepatic origin unless directly attributable to the patient's MCL.Calculated creatinine clearance ≥30 mL/min. Glomerular filtration rate (GFR) ≥30 mL/min directly measured with 24 hour urine collection, or creatinine clearance calculated according to the modified formula of Cockcroft and Gault (for men: GFR ≈ ((140 - age) x bodyweight)/ (72 x creatinine), for women x 0, 85) or an equally accurate method.Able to give voluntary written informed consent.Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty.Negative serum or urine pregnancy test for women of childbearing potential (WOCBP).Willing to comply with the contraceptive requirements of the trial.Exclusion Criteria:Any prior therapy including prior radiotherapy.Central nervous system (CNS) involvement of MCL.Known history of infection with HIV or any uncontrolled active systemic infection (e.g., bacterial, viral or fungal).Hepatitis B or C serologic status: subjects who are hepatitis B core antibody (anti-HB core) positive and who are surface antigen (HBsAg) negative will need to have a negative polymerase chain reaction (PCR) test. Those who are hepatitis B HbsAg positive or hepatitis B PCR positive will be excluded. Those who are hepatitis C antibody and PCR positive will be excluded (those who are hepatitis C antibody positive and PCR negative will not be excluded).Progression requiring treatment within 6 months of initial diagnosis.Vaccinated with live vaccines (not including messenger ribonucleic acid (mRNA), viral vector or other non-live COVID19 vaccines) within four weeks prior to randomisation.Major surgical procedure within 28 days prior to randomisation. Note: If a subject had major surgery, they must have recovered adequately from any toxicity and/or complications from the intervention before the first dose of study drug.Prior malignancy (or any other malignancy requiring active treatment), except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, localised prostate cancer or other cancer from which the subject has been disease free for ≥ 2 years or which will not limit survival to < 5 years.Requirement for moderate or strong CYP3A inducers. Moderate and strong CYP3A inhibitors are allowed although these should be switched to agents causing less CYP3A inhibition where possible.Requirement for vitamin K antagonists (alternative anticoagulation is allowed (e.g. DOACs), but patients must be properly informed about the potential risk of bleeding alongside zanubrutinib).Active bleeding or history of bleeding diathesis (e.g. haemophilia or von Willebrand disease).Clinically significant cardiovascular disease such as uncontrolled arrhythmias, or myocardial infarction within 6 months of screening, or any Class 3 or 4 cardiac disease as defined by the New York Heart Association (NYHA) Functional Classification, or corrected QT interval (QTc) > 480 msec, second-degree atrioventricular block Type II, or third-degree atrioventricular block at screening.History of stroke or intracranial haemorrhage within 6 months prior to study enrolment.Any other severe medical or psychiatric illness that in the opinion of the investigator would interfere with participation in this clinical study.Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel that is likely to affect absorption, symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass.Women who are pregnant or breastfeeding.Male participants with female partners of childbearing potential who are unwilling to use appropriate contraception methods.Concurrent treatment with another investigational agent.History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies, known sensitivity or allergy to murine products.Known hypersensitivity to any active substance or to any of the excipients of one of the drugs used in the trial.