NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Inclusion Criteria:participants must have had a traumatic spinal cord injury at least one year agoregular bowel care routinecan communicate in EnglishExclusion Criteria:cauda equina or conus lesionscurrently use ventilatorcolostomy, or do not perform regular bowel careskin breakdown (pressure sores)cannot communicate in Englishunder 19 years oldpossibly or certainly pregnantmedical/psychiatric condition or substance abuse that is likely to affect ability to complete studycurrently using medications containing PDE-5 inhibitorscurrently using medications containing GTNallergy to GTN