Safety and Tolerance of Increased Doses of HRS-1780 Tablets in Healthy Subjects

This is a randomized, double-blind, placebo-controlled phase I clinical study. The primary objective is to evaluate the safety, tolerability, PK, and PD of single- and multiple-dose HRS-1780 in healthy subjects, and to evaluate the food effect on PK of HRS-1780.

Inclusion Criteria:18-45 years old (including boundary value, whichever is at the time of signing the informed consent form), healthy male.Weight ≥50 kg, body mass index (BMI = body mass/height square (kg/m2)) is in the range of 18-28 (including boundary values)Obtain informed consent before any activity related to the experiment begins, have a full understanding of the purpose and significance of the experiment, and be willing to comply with the test plan and dietary requirements.Subjects (including partners) have no family planning within 3 months from the beginning of the signing of the informed consent form to the last dose, and are willing to adopt the efficient contraceptive measures stipulated in the program and guarantee not to donate sperm.Exclusion Criteria:People with a history of hypertension.People with severe systemic infectious diseases, serious trauma or major surgical surgery before screening; those who plan to undergo surgery during the trialThere has been a history of clinical abnormal gastric emptying and severe chronic gastrointestinal diseases.Diseases found to show clinical significance before screeningCombined with diuretics before screeningDrugs were used 2 weeks before screening.Laboratory or physical examination with any abnormalities and the researcher's judgment is clinically significant.12-lead electrocardiogram is abnormal and of clinical significancePositive for hepatitis B surface antigen, positive for hepatitis C antibody, positive for syphilis spirochete antibody, positive for HIV antibodyPeople with severe allergic diseases or known or suspected of being allergic to any of the ingredients in the research drug, allergic constitution (multiple drugs and food allergies)Participated in the clinical trial of any drug or medical device within the first 3 months of screening or planned to participate in the clinical trial of other drugs or medical devices during the trial period (subject to the signing of informed consent)Drink more than 14 units of alcohol per week in the first 6 months of screening; or those who have taken alcohol products 48 hours before administration; or those who have tested positive for alcohol exhalation during the baseline period.Smoking more than 5 cigarettes a day in the 3 months before screening or using any tobacco products 48 h before administration.Drink/eat coffee, tea, grapefruit, chocolate or soft drinks, such as cola containing methamphetrine (tein, caffeine or cocoaine) within 3 days before screeningThose who have had a history of drug abuse in the past five years or have used drugs in the first three months of the trial; or urine drugs are screened positiveBlood donation ≥ 200 mL within 1 month before screening; or blood donation ≥ 400 mL within 3 months before screening; or trauma or surgical surgery with blood donation (plasma or platelets) or blood loss of ≥ 400 mL within 2 weeksInability tolerate venous puncture and blood collection or dizzinessSubjects who believe that there are other factors that are not suitable to participate in this test