Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery

The aim of this study is to compare the effect of perioperative administration of pregabalin versus dexmedetomidine on the prevalence and lasting duration of delirium in elderly patients after cardiac surgery.

Inclusion Criteria:≥ 65 years of age both genders American Society of Anesthesiologists (ASA) physical status classification II or III scheduled for cardiac surgery.Exclusion Criteria:Patients who had history of psychiatric diseases; inability to communicate; previous history of POD; preoperative sick sinus syndrome.Allergy/sensitivity to pregabalin or dexmedetomidine.Severe bradycardia (heart rate <50 beat per minute).Second-degree or above atrioventricular block without pacemaker.Severe hepatic or renal insufficiency.Previous cardiac or thoracic surgery.Known diagnosis of depression or other major psychiatric diseases.Cognitive impairment or inability to cooperate with the study.Renal insufficiency, and history of substance abuse.