Trastuzumab, Bevacizumab With Paclitaxel for HER2-positive Gastric Cancer in a Second-line Therapy

This is a multicenter, open-label, prospective, phase 2 study of trastuzumab, bevacizumab, and paclitaxel as second-line treatment for patients with HER2-positive advanced gastric cancer who had progressed on first-line chemotherapy including trastuzumab or anti-HER2 agents.

Inclusion Criteria:HER2-positive advanced gastric cancerDefined as IHC 2+, which is IHC 3+ or SISH + (or FISH) evaluated by laboratory tests. (SISH positivity is defined as the ratio of the HER2 gene copy number to the CEP17 signal ≥ 2.0)or significant overexpression of HER2 protein on target proteomic analysis (multiple reaction monitoring)Patients who have progressed in response to one systemic anticancer therapy for advanced gastric cancerPatients who are willing and able to write a written consent form for this trial.Patients aged 19 years or older at the time of signing the subject consent form.Patients with measurable or evaluable lesions according to RECIST 1.1.ECOG activity status 0, 1 or 2as patients with adequate organ functionAbsolute neutrophil (ANC) ≥1.0 x 109/L, platelet ≥100 x 109/L, hemoglobin ≥9 g/dL, serum creatinine ≤1.5 x ULN, total bilirubin ≤3.0 mg on laboratory tests within 2 weeks before starting treatment /dL, AST/ALT ≤5 x ULNEchocardiogram EF ≥55% or MUGA scan ≥50%Exclusion Criteria:Patients who have received chemotherapy, radiation therapy, immunotherapy or targeted therapy for gastric cancer within the past 2 weeks.Patients who have experienced Grade 3-4 gastrointestinal bleeding within 3 monthsPatients who have experienced an arteriovascular embolism event, including but not limited to myocardial infarction, transient ischemic attack, cerebrovascular disorder, or unstable angina within 6 monthsOngoing or active infection, symptomatic congestive heart failure, unstable angina, symptomatic or poorly controlled cardiac arrhythmias, uncontrolled thrombotic or hemorrhagic disorders, or any other serious medical disorder not controlled in the investigator's judgment patient withPatients with a history of gastrointestinal perforation or fistula within 6 months.Concomitant diagnosis of cancer in another site or history of active malignant tumor within the past 3 yearsExcluding fully cured basal cell carcinoma and thyroid cancer, in situ cervical cancer