Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment

This study aims to analyze the immune profiles of patients with Chronic Rhinosinusitis with Nasal polyps (CRSwNP) with and without asthma before and after Mepolizumab.A group of participants with CRS without nasal polyps (CRSsNP) with asthma will be included to compare their immune profiles to CRSwNP.

Inclusion Criteria:Are over the age of 19.Patients with CRSwNP with or without asthma:Asthma confirmed with a spirometry and assessment on previous history of asthma (a methacholine challenge test and atopy testing to document positive or negative history of asthma will be performed if there is no clinical record).Presence or absence of nasal polyps. This can be based on formal exam at Baseline Visit or historical assessment.Patients with CRSsNP with asthma:These patients will not take the study treatment and they will only complete screening and baseline visits.Females of childbearing potential must commit to using an acceptable method of birth control for the duration of the study and they must have a negative urine pregnancy test at each study visit.Exclusion Criteria:Current or past sinonasal or bronchial tumoursSubjects who have been treated with oral antibiotics in the past month prior to surgery.Subjects with known immunodeficiencySubjects with known autoimmune diseaseSmoking history; current or former smokers.Prior lung transplantsSubjects with parasitic (helmintic) infectionSubjects with hypersensitivity; with allergy/intolerance to a monoclonal antibody or biologicFemale participants who are pregnant or breastfeeding