Characterisation of Clinical Phenotypes and Outcomes of Ma2 Patient

Conditions: Autoimmune Encephalitis, Paraneoplastic Syndromes

Sex: All

Ages: 18 Years – N/A

Enrollment: 43

Sponsor: Hospices Civils de Lyon

Location: France

Summary

Paraneoplastic neurological syndromes (PNS) are rare complications of cancer occurring in 0.01% of cases. Their clinical, biological and radiological presentation is heterogeneous and may constitute a diagnostic challenge. Anti-Ma2 PNS are rare diseases with a guarded prognosis. They are most often associated with a seminoma-like testicular tumor but can also be associated with lung cancer. Classically, they present as limbic, diencephalic and/or brainstem encephalitis. Anti-Ma2 antibodies target intracellular receptors and are characteristic of a particular form of encephalitis. Atypical manifestations including narcolepsy-cataplexy, weight gain, sexual dysfunction and motor neuron syndrome have been described and explain the difficulty in diagnosing anti-Ma2 associated PNS. It seems interesting to better characterize the phenotypes of Ma2 patients in order to optimize the diagnosis and follow-up.

Eligibility Criteria

Inclusion Criteria:Neurological disorderAnti-Ma2 positivity in sera or CSFPatient > 18 years oldExclusion Criteria:Patient without clinical dataPatient without Ma2 antibody in sera or CSF

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Source: ClinicalTrials.gov (NCT05645185). StuddyBuddy aggregates publicly available trial information.