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Completed
NCT05648643
Arterial Elastance: A Predictor of Hypotension Due to Anesthesia Induction
Conditions: Hemodynamic Instability, Anesthesia
Sex: All
Ages: 18 Years – N/A
Enrollment: 100
Sponsor: Acibadem University
Location: Turkey
Summary
Hypotension is very common during and after anesthesia induction.
A prolonged fasting period, a patient's underlying comorbidities, a sympathetic blockade by anesthetic agents, vasodilation, a reduction in preload, and cardiac contractility can cause post-induction hypotension.1,2
The relationship of even short-term hypotension with myocardial damage, renal injury, and stroke has been shown in many studies; therefore, it is very important to provide stable anesthesia induction.3
In current anesthesia practice, we can only intervene when hypotension occurs.
If we can identify patients who may experience hypotension during anesthesia induction before it occurs, we can prevent possible postoperative organ dysfunctions by reducing the duration and depth of hypotension with prophylactic fluid and vasopressor administration.
We hypothesized that arterial elastance (Ea) values before anesthesia induction could predict post-induction hypotension.
To test our hypothesis, we aimed to investigate the reliability of the Ea value, which was monitored preoperatively using the pressure analytical recording method (PRAM) to predict the risk of hypotension that may occur after anesthesia induction.
Eligibility Criteria
Inclusion Criteria:Patients with ASA( American Society Of Anesthesiology) physical status 1-3Underwent major elective surgeryRequired intra-arterial blood pressure monitoring before induction.Exclusion Criteria:Under 18 years of ageArrhythmia (atrial fibrillation, frequent premature beat)Severe pre-existing lung diseaseSevere valvular heart diseasemorbid obesityemergency surgery
Source: ClinicalTrials.gov (NCT05648643). StuddyBuddy aggregates publicly available trial information.
