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Completed
NCT05652426
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
Conditions: Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: 1
Enrollment: 6
Sponsor: Duzce University
Location: Turkey
Summary
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their effect on cognitive functions.Methods: In this retrospective study, patients who were scheduled for carotid endarterectomy, examined the MOCA tests before and after the operation and collected blood samples intraoperatively were included between January 2020-2021.
The time periods specified below, blood samples were taken and serums were frozen at -80 celcius all this patients.
Montreal cognitive function assessment test was applied before the operation, 24 hours and 7 days after the operation.
Ten mililiters venous blood samples were collected to examine the status of basal neuron specific enolase, S100B, oxydative stress parameters (HAF-1 and DAF-1) at time intervals.
Time intervals as follow:T1: Peripheral baseline measurements (blood will be taken from arterial blood sampling) + Cerebral Oxymeter levels + Montreal cognitive performance test + Modified Rankin Scale (mRS) T2: 1 minute before clamping (from peripheral and jugular vena blood sampling) + Cerebral Oxymeter levels T3: Before opening clamp(from peripheral and jugular vena blood sampling) + Cerebral Oxymeter levels T4: 24 hours after the procedure.
(peripheral blood sampling) + Montreal cognitive performance test T5: 7 days after the operation.
(peripheral blood sampling) + Montreal cognitive performance test + CO levels+ Modified Rankin Scale (mRS) Results: We found significantly positive corelation between cerebral oxymeter levels, oxydative stress parameters and cognitive performance tests in this six patient.
Eligibility Criteria
Inclusion Criteria:Patients who were scheduled for carotid endarterectomy, examined the MOCA (Montreal cognitive assesment )tests before and after the operation and collected blood samples intraoperatively were included between January 2020-2021.Exclusion Criteria:Irregular diabetes mellitusPregnancyAcute or chronic renal failureLiver failureHistory of previous carotid or brain traumaVasculitisThyroid diseasesAdrenal insufficiencyPatients who cannot perform cognitive function testsAnemia (below 10 g/dl)History of previous stroke in the last 6 monthsPatients with plegia in the dominant upper extremityPatients who will be shunted during the operation.Patients with vertebrobacillary arterial system or ring of Willis anomalyPresence of acute myocardial infarction.Traumatic brain injuries less than 6 months before the study.
Source: ClinicalTrials.gov (NCT05652426). StuddyBuddy aggregates publicly available trial information.
