Observational Clinical Study of the Natural Course and Long-term Prognosis of Patients With Chronic Liver Disease

Chronic liver disease is a global public health problem. Without timely diagnosis and treatment, chronic liver disease can progress to hepatitis, liver fibrosis, and cirrhosis, while causing a variety of complications such as gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, and liver cancer. Early detection and treatment can slow down the progression of chronic liver disease and reduce the burden of patients. This study intends to construct a retrospective-prospective cohort of patients with chronic liver disease by building a multicenter collaborative network to study the disease characteristics, progression patterns, clinical features, natural course and long-term prognosis of chronic liver disease of different etiologies.

Inclusion Criteria:Patients who regularly visit and follow up at the corresponding liver disease centerAll patients meet at least one of the following diagnostic criteria for chronic liver disease:Chronic viral hepatitis BChronic viral hepatitis C ③. Chronic viral hepatitis D ④. Autoimmune liver disease (PBC/AIH/PSC) ⑤. Non-alcoholic fatty liver disease ⑥. Alcoholic liver diseaseExclusion Criteria:First visit diagnosed with hepatocellular carcinoma or after liver transplantation.Combined with other advanced malignant tumors.The patient refused to sign the informed consent form to participate in this study.