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Completed
NCT05653947
Expression of IL-8 Before and After Root Canal Treatment in Patients With Symptomatic Apical Periodontitis
Conditions: Apical Periodontitis
Sex: All
Ages: 20 Years – 50 Years
Healthy volunteers: 1
Phase: NA
Enrollment: 36
Sponsor: Cairo University
Location: Egypt
Summary
This clinical study aimed to Compare the levels of Interleukin 8 before and after root canal treatment in patients with apical periodontitisDiagnosisLocal anesthesiaIsolation and disinfection of the toothTwo-staged access cavity preparationPatency of the root canalsFirst sample collection using paper pointsWorking length determinationChemico-mechanical preparationAfter 1 week, isolation, Second sample collection then obturation of the root canals and restoration of the tooth.Samples will be stored in (-80 C) freezer till collection of all samples then, quantification will be done using ELISA.
Eligibility Criteria
Inclusion Criteria:Medically free patientsSingle canaled teeth diagnosed clinically with symptomatic apical periodontitis.Radiographic widening in the periodontal membrane space.Presence of pain on percussion.Patients' acceptance to participate in the trial.Exclusion Criteria:Medically compromised patients.Pregnant women: Avoid radiation exposure, anesthesia, and medication.If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively.Teeth that shows association with acute periapical abscess or swelling: Need special treatment steps which could involve additional visits with incision and drainage.Presence of periodontal diseaseNon restorabilityImmature teethRadiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
Source: ClinicalTrials.gov (NCT05653947). StuddyBuddy aggregates publicly available trial information.
