ENB Guided MWA Combined With VATS Versus Sequential Surgery for Synchronous Bilateral Multiple Primary Lung Nodules

The goal of this clinical trial is to evaluate the safety and efficacy of ENB guided MWA combined with VATS versus sequential surgery for synchronous bilateral multiple primary lung nodules. Participants will be divided into two group.One group will accepte treatment of ENB guided MWA combined with VATS,another will accepted sequential surgery.

Inclusion Criteria:Aged ≥18 years and ≤80 years;The subjects are diagnosed synchronous bilateral multiple primary lung nodules by HRCTThe primary nodule is diagnosed as lung cancer by preoperative puncture or multidisciplinary discussion, which can be treated with radical surgery.At least one secondary lesion (6mm≤diameter≤20mm, CTR<0.5) is contralateral to the primary nodule，which need treatment after multidisciplinary discussionThe ipsilateral secondary lesions can be treated by sublobar resection at the same timeECOG PS score 0-1The subjects participate voluntarily and sign a written informed consent;Exclusion Criteria:Patients have contraindications of surgery or anesthesiaPatients are unable to undergo bronchoscopyA contralateral secondary lesion is unreachable during ENB planningThere are large blood vessels 2 mm near the contralateral secondary lesionPatients have severe bleeding tendency and coagulation dysfunction which cannot be improved in a short timePatients have interstitial pneumonia, pulmonary fibrosis, or severe emphysemaPatients have diseases,like severe anemia, dehydration, severe nutritional and metabolic disorders, which cannot be cured or improved in a short timePatients have severe systemic infection and fever (>38.5°C)Patients have other malignant tumorsPatients have participated in other clinical trialsInvestigators consider the patient do not fit for the study