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Completed
NCT05664321
Influence of Adiposity and Other Factors on the Gut Microbiota Composition
Conditions: Obesity, Metabolic Syndrome
Sex: Female
Ages: 18 Years – 25 Years
Healthy volunteers: 1
Enrollment: 92
Sponsor: King Saud University
Location: Saudi Arabia
Summary
People who are overweight are getting more and more common in every region of the world.
However, despite significant progress being made in the treatment options available for overweight, the worldwide incidence of overweight has not gone down, and the challenge of overweight has become a worrisome phenomenon of our times.
Additionally, the process that underlie this illness and the etiological variables are not fully comprehended.
As a result, it is absolutely necessary to determine the factors that contribute to obesity and define the responsibilities that each play.
Researchers have devoted a significant portion of the better part of the last decade to studying the microbiota of the gut to determine whether or not it may play a factor in the development of obesity.
Across spite of this, there is a paucity of accessible epidemiological data in Saudi Arabia.
In addition, the relationship between the composition of the "gut microbiota" and obesity indices in youthful women of reproductive age is little understood.
In view of this, we decided to conduct a case study utilizing whole-genome shotgun sequencing to compare the gut microbiota of obese women from Saudi Arabia with that of healthy control participants.
Our findings shed light on the significance of the gut microbiota in obesity and provide useful insight into the creation of a method for the therapy of obesity by means of microbiota transfer of fecal, antibiotics, probiotics, and prebiotics.
In addition, these data reveal prospective targets for guiding the selection of probiotic strains for the needed gut microbiota regulation in the obesity therapy.
Eligibility Criteria
Inclusion Criteria:Females18 to 25 years of ageNormal weight: body mass index (BMI): 18.00-24.99
kg/m2Obese: BMI ≥ 30 kg/m2Exclusion Criteria:Less than 18 years old or above 25 yearsOverweight (BMI); 25.0-29.9
kg/m2)PregnantFollowing specific diets (e.g., calorie-restricted diets)Reported the presence of gastrointestinal diseases in the past eight weeksEndocrine or oncological disease history, psychiatric disorders, anorexia, other medical conditionsUsage of multi-vitamins or vitamin B12 and antibiotics in the past 6 months
Source: ClinicalTrials.gov (NCT05664321). StuddyBuddy aggregates publicly available trial information.
