Concurrent TMS and EEG Pilot Study

This study will investigate the test-retest reliability of transcranial magnetic stimulation (TMS) -evoked potentials (TEPs) as measured by electroencephalography (EEG), using three different TMS protocols over five different brain regions in healthy volunteers. The goal is to compare the test-retest reliability of single pulse, inhibitory and excitatory TMS protocols as well as two distinct targeting approaches. The main questions to answer are:This study will investigate whether the test-retest reliability of TEPs differ across TMS protocols.This study will investigate whether the test-retest reliability of TEPs differ between individualized and non-individualized targeting approaches.

Inclusion Criteria:Medically and psychiatrically healthyBetween the ages of 18 and 65 years oldFluent in English and capable of providing informed consentWilling to remove any jewelry, hair clips, bobby pins, or any other potentially conducting or magnetic objects worn on or near the headExclusion Criteria:Weight greater than 350 lbs (the weight limit of the specialized TMS/EEG chair)Current serious medical or psychiatric illness, or recent heart diseaseAcute intoxication with any drug of abuse, including alcohol or cannabisPregnancyHistory of neurological problems, including epilepsy, seizures, syncope, tinnitus, migraine, or frequent non-migraine (e.g. tension) headachesHistory of head trauma associated with loss of consciousnessLanguage or hearing impairment that would undermine communication regarding consent, study procedures, and overall volunteer safety.Irritable skinFor those undergoing MRI procedures in the current study: Any standard MRI contraindication (including implanted medical devices, metal in the body, or claustrophobia incompatible with MRI procedures)TMS-contraindicated medical devices, including cochlear implants, pacemaker, neurosensory stimulator, implantable defibrillator, insulin pump, clips, stents, or shunts that may be disrupted by or interact with TMS coil operationTaking medications that lower seizure threshold (see Appendix A: List of Contraindicated Medications)