CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study

This clinical trial will investigate the in vivo trafficking of cilta-cel in extramedullary myeloma using 64Cu Super Paramagnetic Iron Oxide Nanoparticle (64Cu SPION) and Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)

Inclusion Criteria: Patients must meet all the following criteria for study entry: 1. Patient has provided written informed consent 2. Patient is \>18 years of age at the time of consent 3. Patient has a documented diagnosis of MM according to the IMWG diagnostic criteria (Appendix 1) 4. Measurable extramedullary disease by any imaging modality (at least one site of disease ≥1cm that has never received radiotherapy or has progressed following radiotherapy). Presence of biochemical measurable disease is not required 5. Have received at least 2 prior lines of therapy including a PTI and an IMiD. Patient must have undergone at least 1 complete cycle of treatment for each line of therapy, unless PD was the best response to the line of therapy (Appendix 2) Note: induction with or without haematopoietic stem cell transplant, consolidation and maintenance therapy is considered a single line of therapy. 6. Have an ECOG Performance Status score of 0 or 1 (Appendix 3) 7. Have a life expectancy of ≥3 months, as judged by the Investigator 8. Able to undergo apheresis for mononuclear cell collection 9. Have clinical laboratory values meeting the following criteria within 7 days prior to registration (enrolment): * Haemoglobin ≥80g/L (recombinant human erythropoietin use is permitted) * ANC ≥1 × 109/L (prior growth factor support is permitted but must be without support in the 7 days prior to the laboratory test) * Platelet count ≥50 × 109/L * Absolute lymphocyte count ≥0.3 × 109/L * AST ≤3.0× ULN * ALT ≤3.0× ULN * Total bilirubin ≤2.0× ULN; except in patients with congenital bilirubinaemia, such as Gilbert's syndrome (in which case direct bilirubin ≤2.0× ULN is required) * Calculated CrCl ≥40mL/min calculated by the Cockcroft-Gault formula (Appendix 4), nuclear medicine assessment or a 24-hour urine collection 10. When a woman is of childbearing potential, the patient must commit either to abstaining continuously from heterosexual intercourse or agree to practice 2 methods of reliable birth control simultaneously. Where one of the methods is highly effective method of contraception (failure rate of \105 Kg and/or height \>185 cm 3. Known claustrophobia 4. Prior treatment with CAR-T therapy directed at any target 5. Received a cumulative dose of corticosteroids equivalent to ≥70mg of prednisone within the 7 days prior to planned apheresis 6. Any prior therapy that is targeted to BCMA 7. Vaccination with an investigational vaccine or live attenuated vaccine (except for COVID-19) within 4 weeks prior to planned conditioning 8. Patient received any anti-tumour therapy as follows, prior to planned apheresis: * Targeted therapy, epigenetic therapy, or treatment with an investigational drug or use of an invasive investigational medical device within 14 days or at least 5 half-lives, whichever is less * Investigational vaccine within 4 weeks * Monoclonal antibody treatment within 21 days * Cytotoxic therapy within 14 days * Radiotherapy within 14 days. However, if the radiation is given for palliative purposes and the radiation portal covered ≤5% of the bone marrow reserve, the patient is eligible irrespective of the end date of radiotherapy 9. Active malignancies (i.e., progressing or requiring treatment change in the last 24 months) other than the disease being treated under study. The only allowed exceptions are: * Non-muscle invasive bladder cancer treated within the last 24 months that is considered completely cured * Skin cancer (non-melanoma or melanoma) treated within the last 24 months that is considered completely cured * Non-invasive cervical cancer treated within the last 24 months that is considered completely cured * Localised prostate cancer (N0M0): * With a Gleason score of ≤6, treated within the last 24 months or untreated and under surveillance * With a Gleason score of 3+4 that has been treated more than 6 months prior to full study screening and considered to have a very low risk of recurrence, or * History of localised prostate cancer and receiving androgen deprivation therapy and considered to have a very low risk of recurrence * Breast cancer: adequately treated lobular carcinoma in situ or ductal carcinoma in situ, or history of localised breast cancer and receiving anti-hormonal agents and considered to have a very low risk of recurrence * Malignancy that is considered cured with minimal risk of recurrence 10. Plasma cell leukaemia at the time of screening (\>2.0 x 109/L plasma cells by standard differential), Waldenström's macroglobulinaemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or primary amyloid light-chain amyloidosis 11. Contraindications or known life-threatening allergies, hypersensitivity, or intolerance to any of the study treatments (if known) or any of their excipients, including boron, mannitol, and dimethyl sulfoxide (refer to IB), or local product prescribing information for complete lists of excipients 12. Pregnant or breast-feeding or planning to become pregnant while enrolled in this study or within 1 year after receiving cilta-cel infusion 13. Plans to father a child while enrolled in this study or within 1 year after receiving cilta-cel infusion 14. Stroke or seizure within 6 months prior to signing PICF 15. Received either of the following: * An allogenic stem cell transplant within 6 months before planned apheresis. Patients who received an allogeneic transplant must have stopped all immunosuppressive medications for 6 weeks without signs of graft-versus-host disease. Patients with active graft-versus-host disease are excluded * An ASCT ≤12 weeks before planned apheresis 16. Known active, or prior history of, CNS involvement or exhibits clinical signs of meningeal involvement of MM 17. Any of the following criterion related to infectious diseases: * Seropositive for HIV * Hepatitis B infection: In the event the infection status is unclear, quantitative viral levels are necessary to determine the infection status (Appendix 6) * Hepatitis C infection (defined as anti -HCV antibody positive or HCV-RNA positive) or known to have a history of hepatitis C NOTE: For patients with positive HCV antibody due to prior resolved disease can be enrolled, only if a confirmatory HCV RNA test is undetectable. For patients with known history of HCV infection, confirmation of sustained virologic response is required for study eligibility, defined as undetectable HCV RNA ≥24 weeks after completion of antiviral therapy. 18. Serious underlying medical or psychiatric condition or disease, that is likely to interfere with study procedures or results, or that in the opinion of the Investigator would constitute a hazard for participating in this study, such as: * Requirement of continuous supplemental oxygen * Evidence of active viral or bacterial infection, requiring systemic antimicrobial therapy, or uncontrolled systemic fungal infection * Active autoimmune disease * Overt clinical evidence of dementia or altered mental status * Any history of Parkinson's disease or other neurodegenerative disorder * Clinically significant cardiac conditions, such as: * NYHA Class III or IV congestive heart failure (Appendix 7) Short title: CARAMEL Page 60 of 128 Version: 1.0 Date: 17th November 2022 * Myocardial infarction or coronary-artery-bypass graft ≤6 months prior to planned apheresis * History of clinically significant ventricular arrhythmia or unexplained syncope, not believed to be vasovagal in nature or due to dehydration * History of severe non-ischemic cardiomyopathy * Impaired cardiac function (LVEF \