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Not Yet Recruiting NCT05668208

Do Extraperitoneal Laparoscopic Surgeries Increase Intracranial Pressure?

Conditions: Intracranial Pressure Increase

Sex: All
Ages: 18 Years – 70 Years
Phase: NA
Enrollment: 60
Sponsor: Konya City Hospital

Location: Turkey

Summary

When the literature is examined, it has been reported in many studies that intracranial pressure increases due to laparoscopic procedures performed in the intraperitoneal area. The mechanism of increased intracranial pressure (ICP) associated with insufflation is most likely due to impaired venous drainage of the lumbar venous plexus at increased intra-abdominal pressure. Changes in ICP can be monitored by ultrasonographic measurement of optic nerve sheath diameter (ONSD), which is a generally accepted simple, reliable and non-invasive ICP measurement technique. In meta-analyses conducted on this subject, it has been revealed that ICP elevation during laparoscopy can be observed with a significant increase in ONSD in the early (0 30 minutes) and late (30-120 minutes) periods during carbondioxid (CO2) pneumoperitoneum.However, the effect of laparoscopic procedures performed in the extraperitoneal area on the central nervous system is not clear. There is not found any study in the literature comparing laparoscopic procedures, especially performed extraperitoneally and transperitoneally, and their effects on intracranial pressure.The aim of the study compare to laparoscopic cholecystectomy performed in the transperitoneal area and (totally extra-peritoneal) TEP inguinal hernia repair performed in the extraperitoneal area in terms of intracranial pressure relationship.

Eligibility Criteria

Inclusion Criteria:18-70 years old,ASA (American Society of Anesthesiologists) I-II,patients who will undergo laparoscopic cholecystectomy with the diagnosis of symptomatic cholelithiasis or TEP due to inguinal hernia.Exclusion Criteria:patients who were switched to open surgery,glaucoma, corneal disease, eye surgery,cerebrovascular disease,any neurological disease,chronic kidney disease,liver cirrhosis,patients whose peritoneum was opened during TEP.

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Source: ClinicalTrials.gov (NCT05668208). StuddyBuddy aggregates publicly available trial information.