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NCT05670808
"The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
Conditions: To Determine the Optimal Doses of Adrenaline in Preventing Blood Loos in Participants Undergoing Supraclavicular Flap Surgery
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: 1
Phase: PHASE1
Enrollment: 90
Sponsor: Dow University of Health Sciences
Summary
Several studies have attempted to calculate the ideal epinephrine concentration for vasoconstriction, however there has been little consensus.
These experiments were carried out on animals, and the degree of vasoconstriction was measured using a variety of methods.
Animal studies aren't always reliable since animal capillary density differs from human capillary density.
Furthermore, because the density of capillaries in the head and neck is 30 to 40% higher than in other parts of the body, previous studies may not adequately reflect the ideal epinephrine concentration for this highly vascular location.
As a result of this study, clinicians will be able to determine the appropriate dose of epinephrine to control intraoperative bleeding.
This study aims to determine the effect of different doses of epinephrine on volume of bleeding in surgical incisions in participants undergoing supraclavicular flap surgery.
Eligibility Criteria
Inclusion Criteria:Age≥ 18 yearsPatients who are undergoing supraclavicular flap surgeryPatients wishing to be a part of study.Either genderExclusion Criteria:• Participants with cardio vascular diseases.Participants with collagen vascular diseasesParticipant who are on non-steroidal anti-inflammatory drugs, anticoagulants, or aspirin. .
Source: ClinicalTrials.gov (NCT05670808). StuddyBuddy aggregates publicly available trial information.