Transcranial Magnetic Stimulation in Disorder of Consciousness in Acute Severe Cerebrovascular Disease Patients

This study is aimed at evaluating the potential of transcranial magnetic stimulation in patients with acute severe ischemic stroke with DoC while assessing patients with a hybrid neural network evaluation model. This model may be the basis for initiating individualized closed-loop neuromodulation treatment in patients with DoC.

Inclusion Criteria:7-28 days after ischemic strokebehavioral profile consistent with a UWS or MCS as assessed with the Coma Recovery Scale Reviseprestroke Modified Ranking Scale(mRS) ≤2Exclusion Criteria:history of vascular malformation or aneurysmal SAH or untreated aneurysm prior to strokedisorder of consciousness prior to strokeimpairment of hearingmetal implants, e.g. stenting, pacemaker, etc.contraindications to MRI, such as claustrophobiahistory of epilepsy or epileptic episodessuffering from serious diseases such as malignant tumors, etc., with expected survival time <1 yearpatient is currently involved with other trials