A Study of Pressure Waveform Analysis in Coronary Artery-II

The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are:Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered.Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively.The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.

Inclusion Criteria:Participants with anginaExclusion Criteria:Severe valvular heart diseaseHistory of asthmaHeart rate less than 50 beats per minutesystolic blood pressure less than 90 mmHg