Magnesium Sulphate Neuroprotective Strategies for Preterm Deliveries

A Cochrane systematic review has confirmed that fetal exposure to magnesium sulphate given before preterm birth has a neuroprotective role. This review also showed a significant reduction in the rate of gross motor dysfunction in early childhood. Early Preterm birth (< 34+0 weeks) and very low birthweight (< 1,500 g) are the principal risk factors for cerebral palsy. Multiple pregnancy accounts for over 10% of preterm births and has a higher incidence of cerebral palsy than singleton pregnancy (twins have 7 times and triplets 47 times the risk of cerebral palsy compared with singletons).

Inclusion Criteria:Women at risk of preterm birth who are between 24+0 and 33+6 weeks of gestation.When early preterm birth is planned or expected within 24 h, regardless of:Plurality or parityReason for the risks of preterm birthAnticipated mode of birthWhether antenatal corticosteroids have been given or notExclusion Criteria:Women with known Hypersensitivity to magnesiumCaution regarding dosage for patients with renal impairmentPreterm delivery after 34 weeks