Effect of Probiotics on Eradication of Persistent H.Pylori Infection

This study aims to investigate the possible safety and efficacy of probiotics (Bifidobacterium Infants, Enterococcus Feacium, and Lactobacillus Acidophilus) on the eradication rate of Helicobacter pylori and the incidence of adverse effects (AEs) of the concurrent rescue regimen in a patient with persistent H. Pylori infection.

Inclusion Criteria:Symptomatic patients with persistent H. pylori infection of both sexes aged ≥ 18 years old years whose infection was previously confirmed by endoscopy and pathology and experienced ≥ 2 previous treatment failures.Exclusion Criteria:Patients with penicillin allergy.Patients who have severe renal or hepatic disease.Patients who have severe cardiovascular, endocrinological or pulmonary disease.Patients with neoplastic diseases in the 5 years previous to recruitment.Patients with neurological or psychiatric pathology.Pregnant and/or lactating femalesPatients with a history of allergic reactions to any medications used in the study.Patients with a history of taking proton pump inhibitors, H2 antagonists, bismuth, or antibiotics (amoxicillin, metronidazole, clarithromycin) in the previous 2 weeks.Patients on N-acetylcysteinePatients on drug or alcohol abuse in the past year.