Tacrolimus for Thrombocytopenia in SS

This 12-week randomized, open-label study evaluates the efficacy and safety of Tacrolimus for Sjogren's syndrome patients with thrombocytopenia.

Inclusion Criteria:Diagnosis of Sjogren's syndrome according to the 2002 revised American-European Consensus Group (AECG) criteria.Baseline platelet counts within 30-80×109/L.Exclusion Criteria:Concomitant other systemic autoimmune diseases.Severe complications of Sjogren's syndrome.Abnormal laboratory tests such as: white blood cell count <2.5x10^9/L, hemoglobin <80 g/L, AST/ALT >1.5 ULN, serum creatine > 1.5 mg/dL.Received glucocorticoids, immunosuppressants, or biological agents within 3 months.Active acute or chronic infections.History of malignancy.Pregnancy or breastfeeding.