Innovative Biotechnological Production of Antioxidant Products

Several natural compounds have been explored as immune-boosting, antioxidant, and anti-inflammatory dietary supplements. Amongst them, hydroxytyrosol a natural antioxidant found in olive products, and endemic medicinal plants have attracted the scientific's community and industry's interest. The safety and biological activity of a standardised supplement containing 10 mg of hydroxytyrosol synthesized using genetically modified Escherichia coli strains and equal amounts (8.33 μL) of essential oils from oregano vulgaris, sage officinalis and crithmum maritimum in an open-label, single-arm, prospective clinical study were studied. The supplement capsules were given to 12 healthy subjects, aged 26-52, once a day for 8 weeks.

Inclusion Criteria:age between 25 and 65 yearsthe absence of any chronic health conditionsadequate understanding of the studyExclusion Criteria:the presence of any chronic health conditions (diabetes, hypertension, dyslipidemia)intake of nutritional supplements over the past 60 daysheavy smokers (≥25 cigarettes/day)high alcohol use (men >14 drinks/week, women >7 drinks/week)