Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane Oxygenation

Sex: All

Ages: 18 Years – N/A

Phase: NA

Enrollment: 10

Sponsor: University Health Network, Toronto

Summary

The goal of this study is to design a pilot trial evaluating the safety, feasibility, pharmacokinetic modeling, and physiological effects of a volatile anesthetic, sevoflurane, directly administered in extracorporeal membrane oxygenation machines.

Eligibility Criteria

Inclusion Criteria:adult patients expected to be on VV ECMO support for a time frame of more than 24 hours and receiving a sevoflurane-based sedation protocol.Exclusion Criteria:lack of informed consent for participationpregnancyserum bilirubin > 150 μmol/Longoing massive blood transfusion requirement (> 50% blood volume transfused in the previous 8 hours)therapeutic plasma exchange and/or renal replacement therapy in the preceding 24 hoursexpected death or withdrawal of life support in the next 48 hours.

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05680545). StuddyBuddy aggregates publicly available trial information.