Prediction of Pulmonary Rehabilitation Outcomes in Patients With Chronic Respiratory Disease Based on Metabolomics: a Prospective Cohort Study

To comprehensively evaluate the pulmonary rehabilitation (PR) outcomes of patients with chronic respiratory disease (CRD), and to screen biomarkers for predicting different PR outcomes of patients with CRD using metabolomics methods, and to build a prediction model.

Inclusion Criteria:For COPDMeets the Global initiative for chronic obstructive lung disease (GOLD) 2022 definition of stable COPD;Age 30-75 years;Lung CT images only showed chronic bronchitis and emphysema;Agree to participate in the study and is able to cooperate with exhaled breath condensate collection.For bronchiectasisLung CT showed bronchiectasis;Age 18-75 years;Spirometry suggests obstructive ventilatory dysfunction: forced expiratory volume in one second (FEV1) is less than 70% of forced vital capacity (FVC) post bronchodilator inhalation.Exclusion Criteria:Asthma or other respiratory diseasesHistory of pulmonary surgeryα1 antitrypsin deficiencyAutoimmune diseasesPatients with acute myocardial infarction, chronic heart failure, severe cerebral infarction or cerebral hemorrhageA history of malignant disease now or within 2 yearsHistory of acute exacerbation or change of medication in the past 4 weeksA history of blood transfusion within the last 4 weeksDrugs or alcohol abuseBreastfeeding or pregnant womenUnable to cooperate with pulmonary rehabilitation for various reasons